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the safety of actonel 5 mg daily in the treatment and prevention of glucocorticoid-induced osteoporosis was assessed in two randomized, double-blind, placebo-controlled multinational trials of 344 patients male 123 and female 221 aged 18 to 85 years who had recently initiated oral glucocorticoid therapy less than or equal to 3 months, prevention study or were on long-term oral glucocorticoid therapy greater than or equal to 6 months, treatment study .

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actonel may be considered in postmenopausal women who are at risk of developing osteoporosis and for whom the desired clinical outcome is to maintain bone mass and to reduce the risk of fracture.

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in the prevention study of patients initiating glucocorticoids, the incidence of vertebral fractures at one year was reduced from 17 in the placebo group to 6 in the actonel group.
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