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The design of orlistat-like probes was based on the general structure of a number of naturally occurring congeners of lipstatin namely lipstatin , esterastin, and valilactone; scheme 1 a , and our previously reported compounds, 1a , 1b , 1c , 1d , 1e , 1f , 1g , 2a , and 3a scheme 1 b ,4a, c in which a terminal c c single bond in one of the aliphatic chains in the parental orlistat structure was substituted for a c c triple bond.

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because it is slow acting and needs to be taken over a prolonged period, results may seem slow, but patients who take an orlistat based product are more likely to maintain this weight loss after they stop taking the product.

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