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Furosemide is added to a treatment regimen for heart failure which includes digoxin.

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signs of digoxin toxicity range from mild inappetance and diarrhea to fatal arrhythmias.

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the effects of digoxin are enhanced by hypokalaemia, hypomagnesia, hypercalcaemia, hypoxia and hypothyroidism and doses may need to be reduced until these conditions are corrected.

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the volume of distribution of digoxin is proportional to lean body weight and doses listed in table 3 assume average body composition.

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