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As with other ssris, paroxetine can cause mydriasis and should be used with caution in patients with narrow angle glaucoma or history of glaucoma.

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table 3 enumerates adverse events reported at an incidence of 5 or greater among elderly patients ages 60 to 88 treated with paroxetine hydrochloride controlled-release tablets who participated in a short-term 12-week placebo-controlled trial in major depressive disorder in which patients were dosed in a range of 12.

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the development of a potentially life-threatening serotonin syndrome or neuroleptic malignant syndrome nms -like reactions have been reported with snris and ssris alone, including treatment with paroxetine hydrochloride controlled-release tablets, but particularly with concomitant use of serotonergic drugs including triptans with drugs which impair metabolism of serotonin including maois , or with antipsychotics or other dopamine antagonists.

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in this trial, patients with pd assigned to paroxetine demonstrated a lower relapse rate compared to patients on placebo see clinical trials .

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